Articles — Project / Lab Report

This research paper aims at exploiting efficient ways of implementing the N-Body problem. The N-Body problem, in the field of physics, predicts the movements and planets and their gravitational interactions. In this paper, the efficient execution of heavy computational work through usage of different cores in CPU and GPU is looked into; achieved by integrating the OpenMP parallelization API and the Nvidia CUDA into the code. The paper also aims at performance analysis of various algorithms used to solve the same problem. This research not only aids as an alternative to complex simulations but also for bigger data that requires work distribution and computationally expensive procedures.

We will study some aspects of the damped driven pendulum. We will see that the trajectory of damped driven pendulum is unpredictable under certain ranges of parameters. Under some conditions, the trajectory behaves like random. A perturbation of initial condition will lead to different result. Several mathematical tools will be introduced in this study.

laboratorio 2 de calculo vectorial ESCUELA COLOMBIANA DE INGENIERIA JULIO GARAVITO

The knowing of politics is mostly an unknown problem on a large scale in Colombia. Here is proposed a web visualization project, in which the historical information of the votes and the elected representatives are presented in an entertaining and inclusive way, in order to generate a feeling of empathy or politician relevance in the spectator creating the assumption that there's a familiar relationship

Propuesta : Amazon

Specialisation Project ENSIMAG 2016.

Bacterial cells can have DNA damage due to transcriptional error, or through the effect of an antibiotic. The SOS response is a bacterial cell program for coping with DNA damage, in which the cell cycle is arrested, and DNA repair is induced. The repairs have high probability in leading to mutagenesis in the bacteria, which can lead to antibiotic resistance. The RecA protein in bacteria is responsible for the activation of the SOS response; therefore, making it a target for inhibition. I elected to use the ubiquitination system, natively used for apoptosis, as a means of targeted degradation of the RecA protein in bacteria prone to mutations. Polyubiquitination of misfolded proteins leads to the breaking down of the protein with the aid of proteasomes, which break down unnecessary proteins through a chemical reaction known as proteolysis. Using random forest-predictors, I determined a statistically high likelihood of ubiquitination of the RecA protein in MRSA, Tuberculosis, and other high risk bacterial infections. I hypothesized that I could foster ubiquitin-tagging on RecA by forcing the protein to misfold. Chaperones are proteins which interact with each other to prevent specific sets of proteins from misfolding. CHIP (C terminus of HSC70-Interacting Protein) is a biomolecule that inhibits interactions between the chaperones of RecA. Adding CHIP, ubiquitin, and 26s proteasomes into the bacterial system, should theoretically lead to the degradation of the RecA protein inside the bacteria. I tested my hypothesis by conducting an assay for monitoring CHIP-mediated ubiquitination, and conducted analysis on the assay using SDS- Page gel electrophoresis, and Western-blotting. The resulting data showed signs of polyubiquitination on the RecA protein, with chains of five or more ubiquitin, showing high drug potential. Adding an antibody drug conjugate, containing all the necessary components of a CHIP-mediated ubiquitination reaction, to common antibiotics can lead to the inhibition of bacterial mutagenesis, and higher antibiotic drug potency.

Machine learning project report. The project aimed at predicting air quality based on weather and its code is available at https://github.com/annisall/mlproject.

Laboratorio 3