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Jacobs Landscape Poster LaTeX Template Version 1.1 (14/06/14) Created by: Computational Physics and Biophysics Group, Jacobs University https://teamwork.jacobs-university.de:8443/confluence/display/CoPandBiG/LaTeX+Poster Further modified by: Nathaniel Johnston (nathaniel@njohnston.ca) This template has been downloaded from: http://www.LaTeXTemplates.com License: CC BY-NC-SA 3.0 (http://creativecommons.org/licenses/by-nc-sa/3.0/)

Information before unblinding regarding the success of confirmatory clinical trials is highly uncertain. Estimates of expected future power which purport to use this information for purposes of sample size adjustment after given interim points need to reflect this uncertainty. Estimates of future power at later interim points need to track the evolution of the clinical trial. We employ sequential models to describe this evolution. We show that current techniques using point estimates of auxiliary parameters for estimating expected power: (i) fail to describe the range of likely power obtained after the anticipated data are observed, (ii) fail to adjust to different kinds of thresholds, and (iii) fail to adjust to the changing patient population. Our algorithms address each of these shortcomings. We show that the uncertainty arising from clinical trials is characterized by filtering later auxiliary parameters through their earlier counterparts and employing the resulting posterior distribution to estimate power. We devise MCMC-based algorithms to implement sample size adjustments after the first interim point. Bayesian models are designed to implement these adjustments in settings where both hard and soft thresholds for distinguishing the presence of treatment effects are present. Sequential MCMC-based algorithms are devised to implement accurate sample size adjustments for multiple interim points. We apply these suggested algorithms to a depression trial for purposes of illustration.

Based on the MUW Poster LaTeX Template and the Jacobs Portrait Poster Adaptado por Augusto Ferreira, Universidade Federal de Lavrasgstfrr@gmail.com

MatPlotLib and Random Cheat Sheet Edited by Michelle Cristina de Sousa Baltazar http://matplotlib.org/api/pyplot_summary.html http://matplotlib.org/users/pyplot_tutorial.html

A christmas wishlist with a pretty background picture, christmas icons for bullets in the itemize and already stamped and postmarked, ready to be shipped to santa.

This is a portrait version of the Jacobs Landscape Poster LaTeX Template, which was created by the Computational Physics and Biophysics Group, Jacobs University, with further modifications by: Nathaniel Johnston and Vel Gayevskiy (of LaTeXTemplates.com/) License: CC BY-NC-SA 3.0 (http://creativecommons.org/licenses/by-nc-sa/3.0/)

For project in dynamical systems.

A look into the viability of GOAs as type I chondrule precursor material within the new heating parameters of the fly by model.

A Poster template with University of Copenhagen logo. Based on the a0poster class was created by Gerlinde Kettl and Matthias Weiser (tex@kettl.de)